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Each of the checks listed below are user-specific, so that each user can customize which checks they would like activated. Activating or de-activating a check can be done at anytime by the user. All drug checking results are provided through the drug and clinical information provided within the First Databank® drug database.

Patient Drug Allergy Check
Drug allergy reactions can result in serious and life threatening consequences and should be carefully considered when prescribing drug therapy. The drug allergy check identifies drugs that are known to have a higher incidence of causing clinically significant allergic reactions. Additionally, drug allergy check identifies cross-sensitivities among related drugs that may cause drug allergy reactions in patients allergic to similar compounds.

ScriptSure checks any patient allergy against all drugs within the database. Potential allergy-causing drugs are struck out and identified as an allergy on-screen.

Drug to Disease ICD-9 Check / Drug to Disease Condition Check
The Drug-Disease checks are designed to create warnings concerning the use of certain drugs in patients with specific health-related conditions and diseases, or patients who have had certain procedures or diagnostic tests. Healthcare professionals can use these warnings to make informed decisions about altering a patient’s drug therapy when these conditions exist.

In order for these checks to be performed within ScriptSure, a condition must be manually entered for a patient.

Drug to Drug Interaction Check
Drug interactions can be costly for patients, insurers, and society. These costs can be measured in terms of bodily harm and physical suffering in addition to extended hospital stays and lost workdays. The need for drug interaction screening is present in a variety of healthcare settings. The Drug to Drug Interaction check is a tool that assists in identifying and preventing drug interactions. The database covers every drug product that is approved for marketing in the United States. The drug to drug interaction database is a clinically reviewed module that reports only the most clinically significant interactions.

ScriptSure checks any current medication against all drugs within the database. Potentially interacting drugs are underlined and identified as an interaction on-screen. Different drug to drug interaction tolerance levels can be selected: ranging from flagging only severe interactions to flagging any and all potential interactions.

Duplicative Therapy Check
Detecting and preventing duplicate therapy improves patient safety and reduces the risk of additive clinical effects by calling the duplications to the attention of healthcare personnel. Additionally, eliminating redundant therapies can reduce the cost of medication therapy. The Duplicate Therapy check offers point-of-care screening to identify potential duplications of drug therapy by comparing new drug orders to drugs that already exist in a patient drug current medication list (profile). This is achieved using the following components:

Duplicate ingredient checking compares the ingredients of the new drug to the ingredients of the active drugs in a patient profile. Duplicate therapy class checking uses specialized therapeutic drug classes developed specifically for duplicate therapy detection.

Additive Side Effect Check
The Side Effects check addresses the problem of drug-induced illness/side effects. The Side Effect check adheres to OBRA patient consultation requirements for advising patients about common, severe side effects of their medications. Detailed and comprehensive lists of side effects can be generated for use in patient monitoring and counseling. The potential for additive side effects between two or more medications can be checked. Situations can be identified where the side effects of a given drug may complicate a patient’s existing medical condition(s). Drug-induced adverse effects can be detected, which facilitates compliance with Joint Commission on Accreditation of Healthcare Organizations (JCAHO) requirements stating that “medication errors and adverse drug reactions shall be reported immediately.”

A specific side-effect tolerance can be selected ranging from incidence rare or very rare to incidence more frequent.

Additive Condition by ICD-9 / Additive Condition Check
Simply put, the Additive Condition checks compare a potential side effect to an existing patient condition. For example, if a patient is being treated for impotency and a drug is known to have a side-effect of impotency, ScriptSure will warn of this situation.

Polypharmacy Check
Polypharmacy is defined in this application as the use of a drug to treat the side effect of another drug. The clinical judgment of the healthcare professional must determine if this therapy is appropriate.

For example, amoxicillin is dispensed to a patient on day one, and on day three of antibiotic use, the same patient presents to the pharmacy with a prescription for loperamide. This new drug carries the indication for diarrhea, matching with amoxicillin’s side effect profile of diarrhea! This case indicates potential polypharmacy conditions. ScriptSure will warn the physician with a polypharmacy warning in this case.

Drug to Food Interaction Check
The Drug to Food Interaction check was designed to provide alerts on the potential of interactions occurring between certain drugs and food components when used in combination. In addition, the Drug-Food Interaction check provides the capability for generating cautions and other advisory information specific to each potential drug-food interaction. Users are provided with condensed hard copy messages and complete monograph information on the nature of the drug-food interaction. It should be noted that the body of evidence available on drug-food interactions is limited and not nearly as extensive, for example, as drug-drug interactions.

A specific Drug to Food tolerance can be selected ranging from minor significance to most significant.

Drug Comment Check
ScriptSure contains the ability to enter a patient-specific drug comment. For example, after a drug has been prescribed a comment can be attached to it. When this check is activated, the comment entered will appear the next time the drug is selected for the same patient. This allows users to track a drugs efficacy for a particular patient.

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